Triethylamine → HCID 70284605, compound

Participants

Reaction Conditions

Reaction Steps

6.6 g triethylamine were added to 10.0 g N-(tert.butoxycarbonyl)glycine in 100 ml dichloromethane. Then 6.2 g ethyl chloroformate in 20 ml dichloromethane were added dropwise at 0° C.; the mixture was stirred for 15 minutes at 0° C., and then a solution of 8.1 g 2-methoxybenzylamine in 25 ml dichloromethane was added thereto dropwise. The mixture was stirred for another 3 hours at room temperature before being extracted once with 100 ml of a 10% aqueous tartaric acid solution. The organic phase was dried over magnesium sulfate, filtered and reduced in volume under a vacuum. 13.9 g N-(tert.butoxycarbonyl)-glycine-(2-methoxybenzyl)amine were obtained, having a melting point of 96-97° C.

Provenance & Evidence