1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 9804977, compound

Participants

Reaction Conditions

Reaction Steps

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU--0.07 ml, 0.48 mmol) was added to a mixture of ethyl 3-(chloro)-6-(3H-imidazo[4,5-c]pyridin-3-ylmethyl)benzo[b]thiophene-2 carboxylate (Preparation 12, 150 mg, 0.4 mmol) and 3-methoxybenzenethiol (0.07 ml, 0.6 mmol) in a mixture of dimethylformamide (1 ml) and tetrahydrofuran (1 ml) under a nitrogen atmosphere. The solution was heated to 60° C. for 6 hours and then partitioned between ethyl acetate and water. The organics were separated and washed with water, dried (magnesium sulfate) and evaporated under reduced pressure. The residue was triturated with diethyl ether and hexane mixture to give the title compound as a colourless solid (155 mg).

Provenance & Evidence