Acetic Acid → HCID 19347985, compound

Participants

Reaction Steps

Sodium hydroxide (1 ml of 1M in water) was added to a solution of ethyl 3-[2-(N,N-dimethylsulfonylamino)phenyl]sulfanyl-6-(3-pyridylmethoxy)benzo[b]thiophene-2-carboxylate (Example 16--185 mg, 0.31 mmol) in methanol (5 ml), and the solution was heated at reflux for 40 minutes. The hot solution was acidified by dropwise addition of acetic acid, diluted with water (5 ml), and cooled. The solid precipitate was isolated by filtration and dried under vacuo to give the title compound as a colourless solid (102 mg).

Provenance & Evidence