Acetic Acid → HCID 19348000, compound

Participants

Reaction Steps

Sodium hydroxide (3 ml of 1M in water) was added to a suspension of ethyl 3-(2-[(methylcarbonyloxy)methyl]phenylsulfinyl)-6-(3-pyridylmethoxy)benzo[b]thiophene-2-carboxylate (Example 35--500 mg, 0.98 mmol) in methanol (15 ml). The mixture was heated to reflux for 30 minutes. The resultant solution was cooled, diluted with water and acidified by dropwise addition of acetic acid. The precipitate was isolated by filtration and washing with water. The solid was recrystallised twice by dissolving in hot methanol, and cooling, to give the title compound as a colourless solid (71 mg).

Provenance & Evidence