Water → HCID 19348409, compound

Participants

Reaction Steps

To a solution of 5-demethoxyfumagillol (280 mg) in N,N'-dimethylformamide (2 ml), thiomethoxide (220 mg) was added, and the mixture was stirred at room temperature for 1 hour. After adding water (20 ml) thereto, the reaction mixture was extracted with isopropyl ether (50 ml). The organic layer was washed with saturated sodium hydrogen carbonate solution (10 ml) and brine (20 ml), dried over anhydrous magnesium sulfate, and filtered. The residue after distilling off the solvent under reduced pressure was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/2) to obtain 180 mg of the title compound as white solid.

Provenance & Evidence