2-Chloroethanol → 1-(2-Hydroxyethyl)-4-methylpiperazine

Participants

Reaction Steps

N-methyl-piperazine (10 g, 100 mmoles) and 2-chloroethanol (8.5 g,100 mmoles) are stirred at 100° C. for 4 hours. 250 ml of acetone are added to the very viscous reaction mixture and the resulting suspension is neutralised with 15 ml of triethylamine. After filtration of the triethylammonium chloride, the solvent is evaporated under reduced pressure. The desired compound is obtained after purification by chromatography on an alumina column (eluent:ethyl acetate) as a colourless oil.

Provenance & Evidence