2,6-Difluorobenzoyl isocyanate → HCID 15451883, compound

Participants

Reaction Steps

200 mg of 2-Fluoro-3,5-dichloro-4-(1-methyl-2,2,3,3,3-pentafluoropropoxy)aniline was stirred in 15 mL 1,2-dichloroethane as 118 mg 2,6-difluorobenzoyl isocyanate in 5 mL 1,2-dichloroethane was added. The mixture was heated under reflux for 30 minutes before lowering heat and stirring overnight. The mixture was then concentrated to half volume and chilled to give 120 mg of 1-(2,6-Difluorobenzoyl)-3-[2-fluoro-3,5-dichloro-4-(1-methyl-2,2,3,3,3-pentafluoropropoxy)phenyl]urea as a white solid. 1H NMR: 10.60 (s, 1H), 9.46 (s, 1H), 8.11 (d, J=8.0 Hz, 1H), 7.54 (m, 1H), 7.08 (t, J=8.7 Hz, 2H), 5.11 (m, 1H), 1.43 (d, J=6.7 Hz, 3H). MS: 524 m/z. IR: 1699(s), 1469(s).

Provenance & Evidence