Trifluoroacetic acid → HCID 9828084, compound

Participants

Reaction Steps

A solution of 1-9 (175 mg, 0.305 mmol), TFA (3 mL) and CH2Cl2 (3 mL) was stirred at ambient temperature for 3.0 hours. The reaction was concentrated and then azeotroped with toluene (3×10 mL). The residue was dissolved in 5:1 AcOH/HCl (36 mL). 10% Pd/C (150 mg) was added and the mixture was shaken under 62 psi of hydrogen gas for 2.0 hours. Following filtration and evaporative removal of the solvent, the residue was chromatographed (silica gel, 10:1:1 EtOH/ NH4OH/H2O) to give 1-10 as a colorless oil.

Provenance & Evidence