HCID 19348565, compound → HCID 19348640, compound

HRID 1637500Notes

Reaction equation

HRID 1637500 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][O:12][Si](C(C)(C)C)(C)C)=[CH:7][C:6]=1[NH:20][C:21](=[O:39])[CH2:22][CH:23]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]([F:38])([F:37])[F:36])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.CCCCCC>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][C:6]=1[NH:20][C:21](=[O:39])[CH2:22][CH:23]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]([F:37])([F:38])[F:36])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 1

HCID 19348565HCID 19348565, compound

Product 1

HCID 19348640HCID 19348640, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Following a procedure similar to that described in Preparation 9, but using N-[2-t-butyl-5-(t-butyldimethylsilyloxymethyl)phenyl]-3-(2-trifluoromethylphenyl)octanamide (prepared as described in Preparation 18) as a starting material, the title compound was obtained as crystals, melting at 147-147.5° C. (from ethyl acetate-hexane).

Workup

  1. customthat described in Preparation 9

Sources & evidence

ORD record
ord-c8bde0317e6d49ee966525c41b7ce713
Source dataset
uspto-grants-2000_03
Patent number
US06040339

Reaction notes

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