Acetone → HCID 86755254, compound

Participants

Reaction Steps

1.2 ml of 1.6 M Jones' reagent were added to a solution of 426 mg (1.0 mmol) of N-(2-t-butyl-5-formylphenyl)-3-(2-trifluoromethylphenyl)octanamide (prepared as described in Preparation 20) in 8 ml of acetone, whilst ice-cooling, and the resulting mixture was stirred at room temperature for 1 hour. At the end of this time, the reaction mixture was washed three times with water and then once with a saturated aqueous solution of sodium chloride, after which it was dried over anhydrous sodium sulfate. The solvent was removed by istillation under reduced pressure, to give 396 mg (yield 90%) of the title compound as crystals, melting at 199-200° C. (from ethyl acetate-hexane).

Provenance & Evidence