tert-Butyl bromoacetate → HCID 19348536, compound

HRID 1637528Notes

Reaction equation

HRID 1637528 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:6]=1[NH:15][C:16](=[O:33])[CH2:17][CH:18]([C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][C:25]=1[O:31][CH3:32])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])([CH3:4])([CH3:3])[CH3:2].Br[CH2:35][C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:6]=1[NH:15][C:16](=[O:33])[CH2:17][CH:18]([C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:35][C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])=[CH:26][C:25]=1[O:31][CH3:32])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 19348488HCID 19348488, compound

Product 1

HCID 19348536HCID 19348536, compound

Procedure

Following a similar procedure to that described in Preparation 45A(i), but using N-(2-t-butyl-5-methoxycarbonylphenyl)-3-(4-hydroxy-2-methoxyphenyl)octanamide (prepared as described in Preparation 46) and t-butyl bromoacetate, the title compound was obtained as a foam-like substance.

Workup

  1. customthat described in Preparation 45A(i)

Sources & evidence

ORD record
ord-92e327eae77740f38c24607769d22692
Source dataset
uspto-grants-2000_03
Patent number
US06040339

Reaction notes

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