HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-oxo-, methyl ester → Methyl 5-oxazolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-oxo-, methyl ester | HCID 70205 | — |
| Reactant | Dimethyl 2,3-dihydroxybutanedioate | HCID 79067 | — |
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Product | Methyl 5-oxazolecarboxylate | HCID 2724619 | — |
Reaction Steps
For B.4274, dimethyl tartrate was oxidised11 to methyl glyoxylate which reacted 12 with tosylmethyl isocyanide to give methyl oxazole-5-carboxylate.13This was reduced by lithium aluminium hydride by the method of Fallab14 to the alcohol.15
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06043228 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-c5a02cef02ce444bae5c507885a2528b |
| Source note | uspto-grants-2000_03 |