Water → HCID 22460786, compound

Participants

Reaction Steps

A solution of 2.3 ml (31.7 mmol) of thionyl chloride in 5 ml of dichloromethane is added dropwise at 0° C. to a solution of 2.5 g (12.6 mmol) of 3-(2-hydroxymethyl-3-methylpyridin-4-yloxy)propan-1-ol in 20 ml of dichloromethane and the mixture is subsequently stirred at room temperature for a further 16 h. Water (20 ml) is then added, and the mixture is adjusted to pH 8 using sodium bicarbonate solution and extracted with 3×20 ml of dichloromethane. The organic extracts are washed with water, dried over magnesium sulfate and concentrated. The residual oil (2.8 g) is employed in stage b) without further purification.

Provenance & Evidence