Potassium Carbonate → [4-(3-Chloropropoxy)-3-methylpyridin-2-yl]methanol

Participants

Reaction Steps

A solution of 2.7 g (10.4 mmol) of the oil from stage b) in 25 ml of methanol is treated with 1.5 g (20.8 mmol) of potassium carbonate and stirred at room temperature for 4 h. The salts are then filtered off and the filtrate is concentrated. The residue is purified by chromatography on silica gel (eluent: ethyl acetate/methanol/ammonia=19:1:0.4). 1.3 g (57%) of the title compound are isolated as a colorless oil which partially crystallizes after standing for a relatively long time. This product is employed directly for the further reaction (Example 15) without additional purification.

Provenance & Evidence