Potassium Carbonate → {3-Chloro-4-[(2-chloroethyl)methylamino]pyridin-2-yl}methanol

Participants

Reaction Steps

1.83 g of 3-chloro-4-[(2-chloroethyl)-methylamino]-pyridin-2-ylmethyl acetate and 250 mg of potassium carbonate in 20 ml of methanol are stirred at room temperature for 8 h. The mixture is then filtered and the filtrate is concentrated. The residue is triturated with diethyl ether. 1.43 g (92%) of the title compound are isolated as a beige solid. M.p. 91-96° C.

Provenance & Evidence