6-[3-(2-Chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitroimidazo[1,2-b]pyridazine → 6-{3-[2-(1H-benzimidazol-2-ylsulfanylmethyl)-3-methylpyridin-4-ylsulfanyl]propylsulfanyl}-3-nitroimidazo[1,2-b]pyridazine hydrochloride

Participants

Reaction Steps

A suspension of 6-[3-(2-chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitroimidazo[1,2-b]pyrid-azine (0.39 g, 0.95 mmol) and 2-mercapto-1H-benzimidazole (160 mg, 1.05 mmol) in isopropanol (50 ml) is heated under reflux for 7 h. After cooling to room temperature, the precipitate is filtered off, washed with isopropanol and dried at 40° C. in vacuo. The title compound (0.46 g, 86%) is isolated as a beige solid. M.p. 200-207° C (dec.).

Provenance & Evidence