Water → S-{3-methyl-4-[3-(3-nitroimidazo[1,2-b]pyridazin-6-ylsulfanyl)propylsulfanyl]-pyridin-2-ylmethyl} thioacetate

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Reaction Steps

A suspension of potassium thioacetate (0.44 g, 3.75 mmol) and potassium carbonate (0.87 g, 6.25 mmol) in 10 ml of dimethylformamide is stirred at room temperature for 30 min and then treated with a solution of 1.03 g (2.5 mmol) of 6-[3-(2-chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitroimidazo[1,2-b]pyridazine in 10 ml of dimethylformamide. The suspension is stirred at room temperature for a further 18 h. Water (100 ml) is then added, and the mixture is cooled to 0° C. and filtered. After drying the solid in vacuo at 40° C., it is additionally suspended in hot diisopropyl ether. After cooling to room temperature, the solid is again filtered and dried. 1.02 g (98%) of the title compound are isolated as a pale beige solid. M.p.: 138-140° C.

Provenance & Evidence