Water → HCID 178431910, compound

Participants

Reaction Steps

A suspension of 0.7 g (1.7 mmol) of 6-[3-(2-chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitroimidazo[1,2-b]pyridazine, 0.275 g (1.7 mmol) of 6-amino-2-mercapto-3H-pyrimidin-4-one monohydrate and 0.18 g (1.7 mmol) of sodium carbonate in 20 ml of isopropanol is heated under reflux for 2.5 h. The suspension is then added to 250 ml of water and stirred at room temperature for 30 min. The precipitate is filtered off, washed with water, dried in a high vacuum and suspended in hot methanol. After filtering and drying again, 0.83 g (94%) of the title compound is isolated as a pale beige solid. M.p.: 244-246° C.

Provenance & Evidence