1,8-Diazabicyclo(5.4.0)undec-7-ene → [2-(1H-Benzimidazol-2-ylsulfanylmethyl)-3-chloro-pyridin-4-yl]methyl-[2-(3-nitroimidazo[1,2-b]pyridazin-6-ylsulfanyl)ethyl]amine

Participants

Reaction Steps

0.44 g (1.0 mmol) of [2-(1H-benzimidazol-2-ylsulfanylmethyl)-3-chloropyridin-4-yl]-(2-chloroethyl)methyl-amine, 0.24 g (1.2 mmol) of 3-nitroimidazo[1,2-b]pyridazine-6-thiol and 0.52 ml (3.5 mmol) of DBU are reacted in 10 ml of dimethylformamide by the procedure described in Example 16. After crystallization from diisopropyl ether, 0.35 g (66%) of the title compound is obtained as a pale beige solid. M.p. 184-185° C.

Provenance & Evidence