Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → HCID 18800799, compound

HRID 1637697Notes

Reaction equation

HRID 1637697 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH:7]1[NH:11][C:10](=[O:12])[CH2:9][CH:8]1[C:13]([F:16])([F:15])[F:14].F[B-](F)(F)F.[CH3:22][O+](C)C>C(Cl)Cl>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH:7]1[CH:8]([C:13]([F:16])([F:14])[F:15])[CH2:9][C:10]([O:12][CH3:22])=[N:11]1

Participants

4

Reactant 2

HCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 18800691HCID 18800691, compound

Product 1

HCID 18800799HCID 18800799, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product material from Example 223 B is treated with trimethyloxonium tetrafluoroborate in DCM by the method of Example 3 to yield 2-[(1,3-dioxolan-2-yl)methyl]-3,4-dihydro-5-methoxy-3-(trifluoromethyl)-2H-pyrrole as a mixture of diastereomers.

Sources & evidence

ORD record
ord-186e9cb215074bf1aa43795f8de502aa
Source dataset
uspto-grants-2000_03
Patent number
US06043261

Reaction notes

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