HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [4-(2-Tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1H-Benzimidazole-6-carbonitrile | HCID 223906 | — |
| Reactant | (4-(2-Tert-butylaminosulfonylphenyl)phenyl-aminocarbonyl]methylene chloride | HCID 10738598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [4-(2-Tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole | HCID 53937819 | 37% |
Reaction Steps
Alkylation of 5-cyanobenzimidazole (2 mmol) with [4-(2-tert-butylaminosulfonylphenyl)phenyl-aminocarbonyl]methylene chloride (2 mmol) in DMF (10 mL) and K2CO3 (4 mmol) at r.t. over 16 hours, followed by purification on thin layer TLC plates, and further isolation by HPLC gave [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-6-cyanobenzimidazole (240 mg, 56%) and [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole (160 mg, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06043257 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-955e97f180b442f0bd10ca277c8ce667 |
| Source note | uspto-grants-2000_03 |