Boron tribromide → HCID 15550151, compound

Participants

Reaction Conditions

Reaction Steps

4-amino-6-chloro-2-(3-methoxyphenylmethylthio)-pyrimidine (36 mg, 0.128 mmol; Cpd #39) is dissolved in methylene chloride (0.25 ml), cooled to 0° C. and treated with a solution of BBr3 (0.32 ml, 0.32 mmol, 1M in methylene chloride). The reaction is stirred at 0° C. for 20 min, then refluxed for 2 hrs. After cooling, the reaction is quenched with water, and refluxed for an additional 30 min. Upon cooling the solid is collected and purified by recrystallization from ethanol/water, mp 147.5-148.5° C.

Provenance & Evidence