Hydrochloric Acid → HCID 178477359, compound

Participants

Reaction Steps

A solution of 4,6-di-(tert-butyldimethylsilyloxy)-2-(1-(2-pyridyl)ethyl)thio-pyrimidine (1.23 g, 2.58 mmol) in 8 ml of tetrahydrofuran is treated with 2 N HCl (5.2 ml, 10.31 mmol, 4.0 equiv.) at room temperature. After 30 min, the reaction mixture is concentrated directly at reduced pressure, diluted with toluene and reconcentrated again. The resulting white solid is triturated with methylene chloride, collected and dried to obtain 0.819 g of crude 4,6-dihydroxy-2-(1-(2-pyridyl)ethyl)thio-pyrimidine hydrochloride.

Provenance & Evidence