Acetonitrile → HCID 492831, compound

Participants

Reaction Conditions

Reaction Steps

A flask is charged with 4,6-dichloro-2-(1-(2-pyridyl)ethyl)thio-pyrimidine (0.560 g, 1.96 mmol), acetonitrile (6.5 ml) and 13 ml of 29 % NH4OH. The contents are stirred at 35° C. for 15 h, poured into 50 ml of water, extracted once with ethyl acetate. The organic layer is washed with a saturated solution of brine (1×30 ml), dried with anhydrous Na2SO4 and concentrated in vacuo. Chromatography is accomplished with 100 g of silica gel, packed and eluted with ethyl acetate-hexane (2:3), to yield 0.491 g (94%) of 4-amino-6-chloro-2-(1-(2-pyridyl)ethyl)thio-pyrimidine.

Provenance & Evidence