(4-Methylpyridin-2-yl)methanol → 4-Methylpyridine-2-carbaldehyde

HRID 1637739Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH:9]=[O:10])[CH:4]=1)#N.OCC1C=C(C)C=CN=1>>[CH3:1][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH:9]=[O:10])[CH:4]=1

Participants

Reactant 2

HCID 12325388(4-Methylpyridin-2-yl)methanol

HCID 147614682-Formylisonicotinonitrile

Product 1

HCID 100118944-Methylpyridine-2-carbaldehydeYield 78%

Procedure

In a manner similar to that described for the preparation of 4-cyano-2-pyridinecarboxaldehyde, 2-hydroxymethyl-4-methylpyridine (2.60 g, 21.14 mmol) provided 2.0 g (78%) of the 4-methyl-2-pyridinecarboxaldehyde.

Sources & evidence

ORD record: ord-922969b7f009456c8061c501e30f29df
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06043248

Reaction notes

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