反应详情

A solution of 2-chloro-3-methoxy-4-vinyl-6-(1-hydroxyethyl)-pyridine (446 mg, 2.09 mmol) in 10 mL of methylene chloride at 0° C. is treated with thionyl chloride (0.227 mL, 3.13 mmol) and stirred at room temperature for 1 h. The reaction is quenched with 15 mL of saturated sodium bicarbonate. The aqueous layer is extracted with 3×10 mL of methylene chloride. The combined organics are dried over potassium carbonate and concentrated in vacuo to provide 447 mg (92%) of 2-chloro-3-methoxy-4-vinyl-6-(1-chloroethyl)-pyridine.

1. customThe reaction is quenched with 15 mL of saturated sodium bicarbonate
2. extractionThe aqueous layer is extracted with 3×10 mL of methylene chloride
3. dry with materialThe combined organics are dried over potassium carbonate
4. concentrationconcentrated in vacuo