2-Methylpyridine → HCID 18799588, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-amino-6-hydroxy-2-(2-naphthylmethyl)thio-5-pyrimidinyl)-1-(dimethyl-tert-butylsilyloxy)ethane (Cpd #280; 104 mg, 0.23 mmol) is treated with 2-picoline (28 μL, 0.28 mmol) and phosphorus oxychloride (0.22 ml, 2.3 mmol). The solution is heated to reflux for 2 hours, stirred overnight at 22° C. then heated again to reflux for an additional hour. The solution was cooled and ice is added. The resultant solid was filtered, washed with cold 50% ethanol, and dried under vacuum. The recovered solids, 81 mg are purified by chromatography (SiO2, 4:1 hexane/ethyl acetate): 64 mg (0.19 mmol, 85%), mp 107-110° C.

Provenance & Evidence