Butylamine → HCID 131721746, compound

HRID 1637812Notes

Reaction equation

HRID 1637812 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C@H:13]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33]Cl)=[CH:27][CH:26]=3)[C@H:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:15][O:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:35]([NH2:39])[CH2:36][CH2:37][CH3:38]>>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C@H:13]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][NH:39][CH2:35][CH2:36][CH2:37][CH3:38])=[CH:27][CH:26]=3)[C@H:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:15][O:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8007ButylamineHCID 86755266HCID 86755266, compound

Product 1

HCID 131721746HCID 131721746, compoundYield 63%

Procedure

From (+,-) cis 7-Benzyloxy4-[4-(2-chloroethyloxy)-phenyl]-3-phenyl-chroman (235 mg, 0.5 mmol) and butylamine (183 mg, 2.5 mmol). The evaporated product was precipitated from ether-petrolether to give 160 mg of material, which was chromatographed as described above.

Workup

  1. customThe evaporated product was precipitated from ether-petrolether

Sources & evidence

ORD record
ord-5d1b2ba622b04bbe8c5cafab09f516c0
Source dataset
uspto-grants-2000_03
Patent number
US06043269

Reaction notes

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