Acetamide → HCID 53775828, compound

HRID 1637845Notes

Reaction equation

C(N)(=O)C.C([O:12][CH2:13][C:14]([N:16]1[CH2:21][CH2:20][CH:19]([C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH2:32][C@H:31]([CH2:33][NH:34][C:35](=[O:37])[CH3:36])[O:30][C:29]3=[O:38])=[CH:24][C:23]=2[F:39])C[CH2:17]1)=[O:15])C1C=CC=CC=1>>[F:39][C:23]1[CH:24]=[C:25]([N:28]2[CH2:32][C@H:31]([CH2:33][NH:34][C:35](=[O:37])[CH3:36])[O:30][C:29]2=[O:38])[CH:26]=[CH:27][C:22]=1[CH:19]1[CH2:20][CH2:21][N:16]([C:14](=[O:15])[CH2:13][OH:12])[CH2:17]1

Participants

Reactant 2

HCID 178Acetamide

HCID 18684848HCID 18684848, compound

Product 1

HCID 53775828HCID 53775828, compound

Procedure

Following the general procedure of EXAMPLE 22, and making non-critical variations but substituting (5S)-N-[[3-[3-fluoro-4-[1-(benzyloxy)acetyl]-3-pyrrolidinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide (EXAMPLE 43) for (S)-(-)-N-[[3-[4-[1-[(benzyloxy)acetyl]-4-piperidinyl]-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, the title compound is obtained, FAB-HRMS calculated for C18H22N3O5F+H: 380.1622. Found: 380.1625.

Sources & evidence

ORD record: ord-0b430eeef0f948a79f155ffa9d7eb0ab
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06043266

Reaction notes

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