HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tryptamine → 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tryptamine | HCID 1150 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperonal | HCID 8438 | — |
| Product | 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline | HCID 201172 | 62.7% |
Reaction Steps
This product was prepared using the same procedure as for Intermediate 1 with tryptamine (20.0 g, 120 mmol), 3,4-methylenedioxybenzaldehyde (20.6 g, 1.1 equiv.) and TFA (18 mL, 2 equiv.) to give the title compound (22 g, 60%) as white crystals after recrystallization from ethanol. MP: 178° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06043252 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-851a225802014ff7a18ab41aabc62016 |
| Source note | uspto-grants-2000_03 |