HCID 86755261, compound → HCID 22252158, compound

HRID 1637889Notes

Reaction equation

HRID 1637889 reaction equation
[O:1]=[C:2]([N:19]1[CH2:31][CH2:30][C:29]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][C:21]=2[CH:20]1[C:32]1[CH:37]=[CH:36][C:35]2[O:38][CH2:39][O:40][C:34]=2[CH:33]=1)/[CH:3]=[CH:4]/[C:5]1[CH:18]=[CH:17][C:8]([CH2:9][O:10][CH2:11][C:12]([O:14]CC)=[O:13])=[CH:7][CH:6]=1>CCO>[O:1]=[C:2]([N:19]1[CH2:31][CH2:30][C:29]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][C:21]=2[CH:20]1[C:32]1[CH:37]=[CH:36][C:35]2[O:38][CH2:39][O:40][C:34]=2[CH:33]=1)/[CH:3]=[CH:4]/[C:5]1[CH:6]=[CH:7][C:8]([CH2:9][O:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:17][CH:18]=1

Participants

3

Reactant 1

HCID 86755261HCID 86755261, compound

Product 1

HCID 22252158HCID 22252158, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The same method as employed in the preparation of Example 79 but starting from a solution of (E)-(4-[3-oxo-3-(1-(3,4-methylenedioxyphenyl)-1,3,4,9-tetrahydro-β-carbolin-2-yl)propenyl]benzyloxy)acetic acid, ethyl ester in EtOH gave after recrystallization from MeOH:H2O the title compound as an off-white solid in a 40% yield. MP: 162-163° C.

Workup

  1. customThe same method as employed in the preparation of Example 79
  2. customgave
  3. customafter recrystallization from MeOH

Sources & evidence

ORD record
ord-605b45ab862a445b9e3c1ce988bf7f8f
Source dataset
uspto-grants-2000_03
Patent number
US06043252

Reaction notes

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