Acetic Anhydride → 1-Acetylindolin-2-one

HRID 1637917Notes

Reaction equation

HRID 1637917 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 321710Oxindole

Product 1

HCID 3237191-Acetylindolin-2-one

Procedure

Prepared by refluxing 2-indolinone with 1 equivalent of acetic anhydride in a bath at 170° C. for 3 hours.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-be76c09f87cf4988a8f75c763653f68f
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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