反应详情

Prepared by reacting 1-acetyl-2-indolinone in concentrated sulphuric acid (5.7 ml/g) at -10° C. with 1.1 equivalents of ammonium nitrate which is added in batches with stirring. After the addition has ended the mixture is stirred for a further 15 minutes, poured onto ice water, the precipitate is filtered off, washed with water and dissolved in ethylacetate. The organic phase is extracted with water, dried, filtered and evaporated down in vacuo. The evaporation residue is stirred with petroleum ether.

1. customPrepared
2. customat -10° C.
3. additionis added in batches
4. additionAfter the addition
5. stirringis stirred for a further 15 minutes
6. additionpoured onto ice water
7. filtrationthe precipitate is filtered off
8. washwashed with water
9. dissolutiondissolved in ethylacetate
10. extractionThe organic phase is extracted with water
11. customdried
12. filtrationfiltered
13. customevaporated down in vacuo
14. stirringThe evaporation residue is stirred with petroleum ether