HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178517250, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone | HCID 54280104 | — |
| Reactant | HCID 178507528 | HCID 178507528 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178517250 | HCID 178517250 | — |
Reaction Steps
Prepared by reacting 1-acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone with 1.5 equivalents of 4-(3-amino-phenyl)-imidazole×2 HCl and 3.25 equivalents of triethylamine in DMF (100° C., for 1.5 hours), subsequent treatment with 5 equivalents of piperidine (20° C., 1 hour) and precipitation with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06043254 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-d5ae9cb894fd42e29f0980695e9cefe6 |
| Source note | uspto-grants-2000_03 |