HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 178518452, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-[(4-Aminophenyl)methyl]-1,3-thiazolidine-2,4-dione | HCID 2768377 | — |
| Reactant | Water ethanol | HCID 19096565 | — |
| Reactant | 1-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone | HCID 54280104 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178518452 | HCID 178518452 | — |
Reaction Steps
Prepared by reacting 1-acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone with 1.2 equivalents of 5-(4-amino-benzyl)-thiazolidin-2,4-dione in DMF (120° C., 1 hour), subsequent treatment with 6.7 equivalents of piperidine (20° C., 1 hour), evaporation in vacuo and trituration with EtOH/water (1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06043254 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-74083151a1ba407cab6eff6facab3c05 |
| Source note | uspto-grants-2000_03 |