HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178517259, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-(Pyrrolidin-1-ylmethyl)aniline | HCID 776852 | — |
| Reactant | HCID 54283663 | HCID 54283663 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178517259 | HCID 178517259 | — |
Reaction Steps
Prepared by reacting 3-[1-chloro-1-(4-bromo-phenyl)methylidene]-5-nitro-2-indolinone with 1 equivalent of 4-(pyrrolidin-1-yl-methyl)aniline and 2 equivalents of Hunig's base in DMF (1 hours, 120° C.), pouring into water, extraction with EtOac, separation of the organic phase and purification thereof by column chromatography on SiO2 with CH2Cl2 /MeOH (15:1) as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06043254 |
| Source dataset | uspto-grants-2000_03 |
| ORD ID | ord-29c4d9ad0ee44b2ca56c15fa6e762f89 |
| Source note | uspto-grants-2000_03 |