Water → HCID 178474536, compound

HRID 1637966Notes

Reaction equation

HRID 1637966 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:34]=[CH:33][C:9]([NH:10]/[C:11](=[C:20]3\[C:21](=[O:32])[NH:22][C:23]4[C:28]\3=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=4)/[C:12]3[CH:17]=[CH:16][C:15]([CH2:18][NH2:19])=[CH:14][CH:13]=3)=[CH:8][CH:7]=2)[N:3]=[CH:2]1.O.[C:36](OC(=O)C)(=[O:38])[CH3:37]>C(O)(=O)C.O1CCOCC1>[NH:1]1[CH:5]=[C:4]([C:6]2[CH:34]=[CH:33][C:9]([NH:10]/[C:11](=[C:20]3\[C:21](=[O:32])[NH:22][C:23]4[C:28]\3=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=4)/[C:12]3[CH:13]=[CH:14][C:15]([CH2:18][NH:19][C:36](=[O:38])[CH3:37])=[CH:16][CH:17]=3)=[CH:8][CH:7]=2)[N:3]=[CH:2]1

Participants

6

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 178509830HCID 178509830, compound

Product 1

HCID 178474536HCID 178474536, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 312751,4-DioxaneSolvent

Procedure

3-{(Z)-1-[4-(1H-imidazol-4-yl)anilino]-1-(4-aminomethyl-phenyl)methylidene}-5-nitro-2-indolinone×H2O is stirred into dry dioxane together with 1.2 equivalents of acetic anhydride and a few drops of glacial acetic acid overnight at ambient temperature. The mixture is evaporated down in vacuo and the evaporation residue is triturated with ether.

Workup

  1. customThe mixture is evaporated down in vacuo
  2. customthe evaporation residue is triturated with ether

Sources & evidence

ORD record
ord-d967162fa6954eb88b784ec9be58ec57
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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