反应详情

A mixture of 1-(tert-butoxycarbonyl)-2,3,6,7-tetrahydro-5-methoxy-(1H)-1,4-diazepine (170 mg, 0.75 mmol) and ammonium chloride (40.1 mg, 0.75 mmol) in 2.0 mL of anhydrous ethanol was refluxed for 3 h. The solvent was then removed in vacuo and residue was triturated with 3×10 mL of ether to give 174 mg of 1-(tert-butoxycarbonyl)-hexahydro-5-imino-(1H)-1,4-diazepine hydrochloride as a light yellow solid.

1. temperaturewas refluxed for 3 h
2. customThe solvent was then removed in vacuo and residue
3. customwas triturated with 3×10 mL of ether