참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,3-Dioxane | HCID 10450 | — |
| 반응물 | N-((2-chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride | HCID 6454011 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Ticlopidine Hydrochloride | HCID 65335 | 82% |
반응 단계
N-[(2-chlorophenyl-methyl)]-2-(2-thienyl)ethylamine HCl (28.8 g) is suspended in 75 ml of iso-propanol. 1,3-Dioxane (13.2 g) and 0.25 ml of hydrochloric acid (37% concentration) are added. The reaction mixture is heated to 80° C. for 24 hours. Thereafter, the mixture is cooled to 10° C. and the precipitate is filtered and washed twice with 10 ml of frozen iso-propanol. The product is desiccated at 60° C. UV to yield 24.6 g (82%) Ticlopidine hydrochloride with chemical-physical characteristics as described in Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06043368 |
|---|
| 출처 데이터셋 | uspto-grants-2000_03 |
|---|
| ORD ID | ord-f9afe6551c06405cb4128657cddb614e |
|---|
| 출처 메모 | uspto-grants-2000_03 |
|---|
