Hydrochloric Acid → Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-((2-methylphenyl)methyl)-, monohydrochloride

Participants

Reaction Conditions

Reaction Steps

N-[(2-methylbenzyl)]-2-(2-thienyl)ethylamine HCl (26.8 g, 0.1 moles) is suspended in 75 ml of 1,3-dioxolane. 0.25 ml of 37% hydrochloride acid is added. The reaction mixture is refluxed for 24 hours. Thereafter, the mixture is cooled to 10° C. and the crystalline precipitate is filtered and washed twice with 5 ml of isopropanol. The product is dried at 60° C. under vacuum to yield 17.4 g (62.7%) of 5-(2-methylbenzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine HCl having a m.p. of 207-210° C.

Provenance & Evidence