Ethanol → HCID 19347459, compound

HRID 1638167Notes

Reaction equation

HRID 1638167 reaction equation
[SH:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[CH2:13]([OH:15])[CH3:14]>>[C:7]1([C:5]2[N:6]=[C:2]3[N:3]([CH:4]=2)[C:5]2[CH2:7][CH2:8][CH2:14][C:13](=[O:15])[C:4]=2[S:1]3)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 178527829HCID 178527829, compound

Product 1

HCID 19347459HCID 19347459, compound

Procedure

2-Mercapto-4-phenylimidazole (10.6 g) and 2-bromo-1,3-cyclohexadione (12.6 g) were placed into absolute ethanol (200 ml) and the reaction mixture was heated to reflux for 16 hours and then cooled to give hydrobromide salt of the desired compound (16.3 g). The hydrobromide salt was neutralized with 10% sodium carbonate solution in an aqueous system to give the titled compound (12.3 g, 76%).

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 16 hours
  3. temperaturecooled

Sources & evidence

ORD record
ord-55c50f3e51144cbba9038c4e28bb6e55
Source dataset
uspto-grants-2000_03
Patent number
US06043373

Reaction notes

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