HCID 19347464, compound → HCID 19347462, compound
Reaction equation
[C:1]([C:4]1[S:5][C:6]2[C:12](=[O:13])[CH:11]([Br:14])[CH2:10][CH2:9][C:7]=2[N:8]=1)(=[NH:3])[NH2:2].C(NC(N)=S)(=N)N>>[BrH:14].[C:1]([C:4]1[S:5][C:6]2[C:12](=[O:13])[CH2:11][CH2:10][CH2:9][C:7]=2[N:8]=1)(=[NH:2])[NH2:3]Participants
3
Procedure
2-Bromo-1,3-cyclohexadione prepared in Example 1, Route 1 (A) was reacted with amidinothiourea in the similar manner to that of Example 1, Route 1(B) to give 2-amidino-4,5-dihydrobenzothiazole-7(6H)-one hydrobromide. The hydrobromide (3.4 g) was dissolved into conc. hydrobromic acid (20 ml), and one equivalent of bromine was added dropwise at a temperature of 85° C. The mixture was stirred at a temperature of 80° C. to 90° C. for 30 minutes, cooled and filtered. The solids were neutralized with sodium carbonate to give the titled compound (3.17 g, 67%).
Sources & evidence
- ORD record
- ord-5047b269d07843e198a8e3e514080d02
- Source dataset
- uspto-grants-2000_03
- Patent number
- US06043373
Reaction notes
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