3-(Trifluoromethyl)benzyl chloride → HCID 18801226, compound

HRID 1638201Notes

Reaction equation

HRID 1638201 reaction equation
Cl.[CH:2]1([N:12]2[CH2:28][CH2:27][C:15]3([N:19]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:18][NH:17][C:16]3=[O:26])[CH2:14][CH2:13]2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[F:29][C:30]([F:40])([F:39])[C:31]1[CH:32]=[C:33]([CH:36]=[CH:37][CH:38]=1)[CH2:34][Cl:35]>>[ClH:35].[CH:2]1([N:12]2[CH2:28][CH2:27][C:15]3([N:19]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:18][N:17]([CH2:34][C:33]4[CH:36]=[CH:37][CH:38]=[C:31]([C:30]([F:29])([F:39])[F:40])[CH:32]=4)[C:16]3=[O:26])[CH2:14][CH2:13]2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 697163-(Trifluoromethyl)benzyl chlorideHCID 19347388HCID 19347388, compound

Product 1

HCID 18801226HCID 18801226, compound

Procedure

The title compound, white solid, m. p. 197° C. and MS: m/e=528.3 (M+H+) was prepared in accordance with the general method of example 24 from 8-cyclodecyl-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one hydrochloride and 3-trifluoromethylbenzylchloride.

Sources & evidence

ORD record
ord-2005c979decf4ddb84eac96ffad9a47b
Source dataset
uspto-grants-2000_03
Patent number
US06043366

Reaction notes

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