Ethyl orthoformate → HCID 10496886, compound

Participants

Reaction Conditions

Reaction Steps

4-(p-tolyl-amino)-1-(phenylmethyl)-4-piperidine-carboxamide (1.62 g) was dissolved in 10 ml triethyl orthoformate and stirred at 150° C. for 15 hours. After cooling to room temperature, the reaction mixture was filtered and the light brown powder washed with ether to yield 8-benzyl-1-p-tolyl-1,3,8-triazaspiro[4,5]dec-2-en-4-one (0.99 g). M.p. 208-213° C.

Provenance & Evidence