HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1638215Generated: October 31, 2026
Ethyl orthoformate → HCID 18801217, compound
https://huagongshe.com/reaction/1638215
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 1-Benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide | HCID 70587 | — |
| Product | HCID 18801217 | HCID 18801217 | — |
Reaction Steps
4-(4-chloro-phenyl-amino)-1-(phenylmethyl)-4-piperidine-carboxamide (6.47 g) was dissolved in 31 ml triethyl orthoformate and stirred at 150° C. for 10 d. After cooling to 0° C., the reaction mixture was filtered and the light brown powder washed with ether to yield 8-benzyl-1-4-chloro-phenyl-1,3,8-triazaspiro[4,5]dec-2-en-4-one (3.90 g). M.p. 217-219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06043366 |
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| Source dataset | uspto-grants-2000_03 |
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| ORD ID | ord-843253791e4d4aa0a057b1b6b698188e |
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| Source note | uspto-grants-2000_03 |
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