Ammonia → HCID 20068400, compound

HRID 1638259Notes

Reaction equation

HRID 1638259 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[N:12]1[C:16]([C:17]#[N:18])=[CH:15][N:14]=[CH:13]1.N.[H][H]>[Ni].CO>[CH3:1][C:2]1([CH3:19])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[N:12]1[C:16]([CH2:17][NH2:18])=[CH:15][N:14]=[CH:13]1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 20068370HCID 20068370, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20068400HCID 20068400, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 25 parts of 1-(1,2,3,4-tetrahydro-2,2-dimethyl-1-naphthalenyl)-1H-imidazole-5-carbonitrile and 360 parts of methanol, saturated with ammonia was hydrogenated at normal pressure and at room temperature with 2 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was dried at 100° C., yielding 23 parts (90.0%) of 1-(1,2,3,4-tetrahydro-2,2-dimethyl-1-naphthalenyl)-1H-imidazole-5-methanamine as an oily residue (compound 2.37).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. customThe residue was dried at 100° C.

Sources & evidence

ORD record
ord-81f87b08d82e4f6587ca540aac951337
Source dataset
uspto-grants-1989_11
Patent number
US04878940

Reaction notes

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