HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ipsapirone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| Reactant | 1,1-Dioxido-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)-one | HCID 10781774 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ipsapirone | HCID 56971 | — |
Reaction Steps
0.02 mol of 2-(4-bromobutyl)-1,2-benzoisothiazol-3-(2H)one 1,1-dioxide and 0.02 mol of 1-(2-pyrimidinyl) piperazine are stirred with 0.02 mol of K2CO3 in 150 ml of absolute dimethylformamide (DMF) for 1 hour at 100° C. The mixture is then concentrated. Water is added to the residue and the organic substance is taken up in methylene chloride (CH2CL2). The dried CH2CL2 phase is added to a silica gel column and eluted with CH2CL2 /CH3OH (95:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04879290 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-e431c64b54da497b92c48fb6202fbcf2 |
| Source note | uspto-grants-1989_11 |