Acetic Anhydride → HCID 15623069, compound

HRID 1638312Notes

Reaction equation

HRID 1638312 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>N1C=CC=CC=1>[C:16]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1360771662-(2-Hydroxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 15623069HCID 15623069, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 2-(2-hydroxyphenyl)-4-thiazolecarboxylic acid (900 mg) dissolved in dry pyridine (15 ml) was added dropwise acetic anhydride (0.461 ml) under ice-cooling. The mixture was allowed to warm up to room temperature and to react for additional 1.5 hours. Then the solvent was removed and the residue was treated with water, acidified with 2N--HCl and extracted with ethyl acetate. The extract was washed with water, dried and concentrated to give the desired compound,

Workup

  1. temperaturecooling
  2. customto react for additional 1.5 hours
  3. customThen the solvent was removed
  4. additionthe residue was treated with water
  5. extractionHCl and extracted with ethyl acetate
  6. washThe extract was washed with water
  7. customdried
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-d8e292dda12342568ffaaa6e8d5c9e5d
Source dataset
uspto-grants-1989_11
Patent number
US04879295

Reaction notes

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