Potassium Hydroxide → 2-(2-Furyl)thiazolidine-4-carboxylic acid, 97%

HRID 1638317Notes

Reaction equation

HRID 1638317 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][CH:8]=[C:9]([C:11]([O:13]CC)=[O:12])[N:10]=1.[OH-].[K+]>CO>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 19842281HCID 19842281, compound

Product 1

HCID 156230722-(2-Furyl)thiazolidine-4-carboxylic acid, 97%Yield 46%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of ethyl 2-(2-furyl)-4-thiazole carboxylate (3.12 g) in methanol (30 ml) was added dropwise 1N aqueous potassium hydroxide (38.58 ml) and the mixture was at 55° C. for 15 minutes. Then the solvent was removed from the reaction mixture, and the residue was treated with water and acidified with 2N-HCl under ice-cooling. The resulting solids were sucked, washed with water and dried to give yellowish crystals of 2-(2-furyl)-4-thiazole carboxylic acid (1.16 g, yeild 46%), m.p. 257°-265° C.

Workup

  1. customThen the solvent was removed from the reaction mixture
  2. additionthe residue was treated with water
  3. temperaturecooling
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-2cbdf423636245718634ab014ce916aa
Source dataset
uspto-grants-1989_11
Patent number
US04879295

Reaction notes

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