Potassium Hydroxide → 5-Methyl-2-(5-methyl-2-thienyl)-4-thiazolecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-(5-methyl-2-thienyl)-5-methyl-4-thiazolecarboxylate (1.47 g) in methanol (100 ml) was added 1N aqueous potassium hydroxide (16.5 ml) and the mixture was heated at 60° C. for 40 minutes. Then the solvent was removed from the reaction mixture. The residue was treated with water and acidified with 2N hydrochloric acid under ice-cooling. The deposited solids were filtered and washed with water, recrystallized from methanol-water to give yellowish crystals of 2-(5-methyl-2-thienyl)-5-methyl-4-thiazolecarboxylic acid (1.06 g, yield 80%), m.p. 160°-161° C.

Provenance & Evidence